Methyl Methylsalicylate

INCI: METHYL METHYLSALICYLATE

CAS Number
Not definitively confirmed — this is the methyl ester of methylsalicylic acid (distinct from methyl salicylate, CAS 119-36-8). Possible CAS: 22717-57-3 (methyl 3-methylsalicylate) or positional isomers
Function
Fragrance agent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes Permitted — no specific CFR prohibition for this distinct INCI

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Structural proximity to methyl salicylate (CMR 2): while this is a different substance, a CPSR assessor should apply read-across rationale cautiously. Metabolic hydrolysis could yield methylsalicylic acid. SCCS has imposed strict concentration limits on methyl salicylate (0.06% leave-on skin, 0.05% face makeup). Consider whether analogous restrictions should apply by precautionary read-across.

⚠️
Concern Level: High

Regulatory Flags

fragrance-component

Frequently Asked Questions

Is Methyl Methylsalicylate safe in cosmetics?

Structural proximity to methyl salicylate (CMR 2): while this is a different substance, a CPSR assessor should apply read-across rationale cautiously. Metabolic hydrolysis could yield methylsalicylic acid. SCCS has imposed strict concentration limits on methyl salicylate (0.06% leave-on skin, 0.05% face makeup). Consider whether analogous restrictions should apply by precautionary read-across. The EU classifies Methyl Methylsalicylate as "restricted". Safety rating: MODERATE.

Is Methyl Methylsalicylate allowed in the EU?

Methyl Methylsalicylate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl Methylsalicylate do in cosmetics?

Methyl Methylsalicylate functions as: Fragrance agent. It is classified as a cosmetic ingredient in our database. CAS number: Not definitively confirmed — this is the methyl ester of methylsalicylic acid (distinct from methyl salicylate, CAS 119-36-8). Possible CAS: 22717-57-3 (methyl 3-methylsalicylate) or positional isomers.

What is the Margin of Safety for Methyl Methylsalicylate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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