Moderate Cosmetic Ingredient NOAEL Data

Dihydrocitronellol

INCI: DIHYDROCITRONELLOL

CAS Number
106-21-8
Function
Fragrance
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted โ€” no 21 CFR restriction; RIFM assessed as part of acyclic terpene alcohol group

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Dihydrocitronellol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 150 mg/kg bw/day oral rat oral REACH

Expert Verdict

Structural analogue of EU-listed allergen citronellol; must declare if EU expands allergen labelling post-SCCS 2023. IFRA restricts use levels by product category. Recommend HRIPT data or RIFM monograph reliance for CPSR.

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Dihydrocitronellol safe in cosmetics?

Structural analogue of EU-listed allergen citronellol; must declare if EU expands allergen labelling post-SCCS 2023. IFRA restricts use levels by product category. Recommend HRIPT data or RIFM monograph reliance for CPSR. The EU classifies Dihydrocitronellol as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Dihydrocitronellol allowed in the EU?

Dihydrocitronellol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Dihydrocitronellol do in cosmetics?

Dihydrocitronellol functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 106-21-8.

What is the Margin of Safety for Dihydrocitronellol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Dihydrocitronellol?

The NOAEL (No Observed Adverse Effect Level) for Dihydrocitronellol is 150 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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