Methyl-Methylthiopyrazine

INCI: METHYL-METHYLTHIOPYRAZINE

CAS Number
67952-65-2 (isomer 2-methyl-3-(methylthio)pyrazine has CAS 2882-20-4)
Function
Fragrance and flavoring agent - roasted/nutty/cocoa-type character
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Allowed - also recognized as a flavoring substance under FDA food additive regulations; not prohibited in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

The pyrazine class is generally considered of low toxicity. The methylthio group imparts potency at very low levels, meaning exposure concentrations are inherently low.. Dual-use ingredient (fragrance and flavor). Extremely potent odorant; effective at ppb-level concentrations. The sulfur-containing pyrazine ring provides characteristic roasted/earthy notes.

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Concern Level: High

Regulatory Flags

fragrance-component

Frequently Asked Questions

Is Methyl-Methylthiopyrazine safe in cosmetics?

The pyrazine class is generally considered of low toxicity. The methylthio group imparts potency at very low levels, meaning exposure concentrations are inherently low.. Dual-use ingredient (fragrance and flavor). Extremely potent odorant; effective at ppb-level concentrations. The sulfur-containing pyrazine ring provides characteristic roasted/earthy notes. The EU classifies Methyl-Methylthiopyrazine as "permitted". Safety rating: MODERATE.

Is Methyl-Methylthiopyrazine allowed in the EU?

Methyl-Methylthiopyrazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Methyl-Methylthiopyrazine do in cosmetics?

Methyl-Methylthiopyrazine functions as: Fragrance and flavoring agent - roasted/nutty/cocoa-type character. It is classified as a cosmetic ingredient in our database. CAS number: 67952-65-2 (isomer 2-methyl-3-(methylthio)pyrazine has CAS 2882-20-4).

What is the Margin of Safety for Methyl-Methylthiopyrazine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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