Myristyl Isostearate
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Myristyl Isostearate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | - | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 300 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Alkyl ester emollient rated safe by CIR Expert Panel when formulated to be non-irritating; potential for mild comedogenicity warrants consideration in sensitive formulations.
Frequently Asked Questions
Is Myristyl Isostearate safe in cosmetics?
Alkyl ester emollient rated safe by CIR Expert Panel when formulated to be non-irritating; potential for mild comedogenicity warrants consideration in sensitive formulations. The EU classifies Myristyl Isostearate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Myristyl Isostearate allowed in the EU?
Myristyl Isostearate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Myristyl Isostearate do in cosmetics?
Myristyl Isostearate functions as: Softener and conditioner. It is classified as a cosmetic ingredient in our database. CAS number: 72576-80-8.
What is the Margin of Safety for Myristyl Isostearate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Myristyl Isostearate?
The NOAEL (No Observed Adverse Effect Level) for Myristyl Isostearate is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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