Moderate Cosmetic Ingredient NOAEL Data

N,N-DIETHYL-M-AMINOPHENOL

CAS Number

91-68-9

Function

Hair Dyeing

Safety Rating

MODERATE

Regulatory Status

🇪🇺 EU Status Restricted

EU Max Conc. II/1223

🇺🇸 US Status prohibited

US Notes Allowed — remains usable under the coal tar hair dye exemption (FD\&C Act); not specifically banned by FDA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

8 study endpoints found for N,N-DIETHYL-M-AMINOPHENOL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
LOEL	26.91227 other	1991	rat	inhalation	REACH
NOAEL	419 mg/kg bw/day	oral	rat	oral	REACH
LOAEL	8333.33 mg/kg bw/day	dermal	code:3543	dermal	REACH
NOAEL	27.5 mg/kg bw/day	oral	rat	oral	REACH
LOAEL	1000 other	9155	rat	inhalation	REACH
NOAEL	75 mg/kg bw/day	oral	mouse	oral	REACH
NOAEL	32 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	225 mg/kg bw/day	oral	mouse	oral	REACH

Expert Verdict

N,N-DIETHYL-M-AMINOPHENOL is listed in the EU CosIng database with functions: Hair Dyeing It is restricted under EU Cosmetics Regulation. Restriction: II/1223.

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Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted needs-enrichment

Frequently Asked Questions

Is N,N-DIETHYL-M-AMINOPHENOL safe in cosmetics?

N,N-DIETHYL-M-AMINOPHENOL is listed in the EU CosIng database with functions: Hair Dyeing It is restricted under EU Cosmetics Regulation. Restriction: II/1223. The EU classifies N,N-DIETHYL-M-AMINOPHENOL as "Restricted". Safety rating: MODERATE. 8 toxicological study endpoint(s) are available in our database.

Is N,N-DIETHYL-M-AMINOPHENOL allowed in the EU?

N,N-DIETHYL-M-AMINOPHENOL EU regulatory status: Restricted. Maximum allowed concentration: II/1223. This is based on EU Regulation 1223/2009 and its amendments.

What does N,N-DIETHYL-M-AMINOPHENOL do in cosmetics?

N,N-DIETHYL-M-AMINOPHENOL functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 91-68-9.

What is the NOAEL for N,N-DIETHYL-M-AMINOPHENOL?

The NOAEL (No Observed Adverse Effect Level) for N,N-DIETHYL-M-AMINOPHENOL is 26.91227 other based on a inhalation study via 1991 route in rat. A total of 8 study endpoints are available. Source: REACH.

Compliance Tools

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Heavy Metal Limits

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ACID RED 51

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