Is NARINGENIN safe in cosmetics?
NARINGENIN has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
NARINGENIN
Also known as: (S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, EINECS 207-550-2, Narigenin, 5,7,4'-Trihydroxyflavanone, UNII-HN5425SBF2 (+6 more)
NARINGENIN (CAS 480-41-1) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 480-41-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
InChIKey
FTVWIRXFELQLPI-ZDUSSCGKSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: ERα, ERβ, AR
LOEC: 100 nM
EU status: allowed
agonist (ERα, ERβ); antagonist (AR)
Additional Ingredient Properties
4 property records from structured ingredient metadata.
acne
{"cas_number": "67604-48-2", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_aging
{"anti_aging_claim": "antioxidant-protection, anti-inflammatory", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "6-12", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "No", "placebo_controlled": "Yes", "published_journal…
anti_pollution
{"cas_number": "67604-48-2", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulati…
depigmentation
{"cas_number": "67604-48-2", "ingredient_class": "tyrosinase_inhibitor", "primary_mechanism_of_action": "Flavanone with tyrosinase inhibition", "secondary_mechanisms": "Variable", "molecular_target": "tyrosinase", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-30", "onset_of_vi…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for NARINGENIN.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
endocrine_disruptor
Known Synonyms
(S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
EINECS 207-550-2
Narigenin
5,7,4'-Trihydroxyflavanone
UNII-HN5425SBF2
(-)-(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one
(2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
(2S)-Naringenin
(S)-2,3-dihydo-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Asahina
pelargidanon
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NARINGENIN
ChEMBL ID
CHEMBL9352
Frequently Asked Questions
Is NARINGENIN allowed in the EU?
NARINGENIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NARINGENIN do in cosmetics?
NARINGENIN functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 480-41-1.
Is NARINGENIN used outside cosmetics?
NARINGENIN also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check NARINGENIN compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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