Is NATAMYCIN safe in cosmetics?
NATAMYCIN has a safety rating of "GOOD" in our database. EU status: permitted. 3 toxicological study endpoint(s) are available in our database.
NATAMYCIN
Also known as: δ-Natamycin, [1R-(1R*,3S*,5R*,7R*,8E,12R*,14E,16E,18E,20E,22R*,24S*,25R*,26S*)]-22-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid, natamycine, natamicina, Acido 6,11,28-trioxatriciclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaeno-25-carboxilico, 22-[(3-amino-3,6-dideoxi-β-d-manopiranosil)oxi]-1,3,26-trihidroxi-12-metil-10-oxo-, (1r,3s,5r,7r,8e,12r,14e,16e,18e,20e,22r,24s,25r,26s)- (+11 more)
NATAMYCIN (CAS 7681-93-8) is a cosmetic cosmetic ingredient functioning as Antimicrobial, Preservative. NOAEL 1 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7681-93-8 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial, Preservative
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
InChIKey
NCXMLFZGDNKEPB-FFPOYIOWSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for NATAMYCIN. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 15 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 40 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for NATAMYCIN across SCCS product categories, with measured dermal absorption where available.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Evaluation
PIMARICIN | 2024 | 0–0.3 mg/kg bw | Based on the available data, JECFA concluded that there is no concern for the induction of antimicrobial resistance and that the risk of natamycin having a disrupting effect on the microbiome of the human gastrointestinal tract is low. JECFA re-affirmed the ADI of 0–0.3 mg/kg bw for natamycin established by the previous Committee at its Twentieth meeting. JECFA
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Preservative
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for NATAMYCIN.
Regulatory Flags
cosing-sourced
eu-permitted
preservative
needs-enrichment
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to NATAMYCIN by CAS number or substance name.
Studies
3
Lowest NOAEL
15 mg/kg bw/day
Highest NOAEL
50 mg/kg bw/day
COSMOS_DB
Known Synonyms
δ-Natamycin
[1R-(1R*,3S*,5R*,7R*,8E,12R*,14E,16E,18E,20E,22R*,24S*,25R*,26S*)]-22-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
natamycine
natamicina
Acido 6,11,28-trioxatriciclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaeno-25-carboxilico, 22-[(3-amino-3,6-dideoxi-β-d-manopiranosil)oxi]-1,3,26-trihidroxi-12-metil-10-oxo-, (1r,3s,5r,7r,8e,12r,14e,16e,18e,20e,22r,24s,25r,26s)-
Pimaricin
Antibiotic A-5283
Delvolan
Delvopos
EINECS 231-683-5
Pimaricine
16-(3-Amino-3,6-didesoxy-beta-D-mannopyranosyloxy)-5,6-epoxy-8,12,14-trihydroxy-26-methyl-2,10-dioxo-1-oxacyclohexacosa-3,17,19,21,23-pentaen-13-carbonsaeure
Natafucin
Natamycinum
Pimarizin
UNII-8O0C852CPO
Chemical Function
Biocide
Preservative
Regulatory Lists
active_ingredient; Pesticides
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NATAMYCIN
ChEMBL ID
CHEMBL1200656
Max Phase
4
Adverse Event Associations
393
Frequently Asked Questions
Is NATAMYCIN allowed in the EU?
NATAMYCIN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NATAMYCIN do in cosmetics?
NATAMYCIN functions as: Antimicrobial, Preservative. It is classified as a cosmetic ingredient in our database. CAS number: 7681-93-8.
What is the NOAEL for NATAMYCIN?
The NOAEL (No Observed Adverse Effect Level) for NATAMYCIN is 15 mg/kg bw/day based on a Chronic study via oral route in dog. A total of 3 study endpoints are available. Source: COSMOS_DB.
Is NATAMYCIN used outside cosmetics?
NATAMYCIN also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check NATAMYCIN compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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