NATAMYCIN
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for NATAMYCIN. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 15 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 100 mg/kg bw/day | oral | rat | Reproductive-developmental | COSMOS_DB |
| NOAEL | 40 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 15 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| dose_tested | 100 mg/kg bw/day | oral | rat | Reproductive-developmental | COSMOS_DB |
| dose_tested | 50 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
Expert Verdict
NATAMYCIN is listed in the EU CosIng database with functions: Antimicrobial, Preservative It is permitted in the EU without specific restrictions.
Regulatory Flags
Frequently Asked Questions
Is NATAMYCIN safe in cosmetics?
NATAMYCIN is listed in the EU CosIng database with functions: Antimicrobial, Preservative It is permitted in the EU without specific restrictions. The EU classifies NATAMYCIN as "Permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is NATAMYCIN allowed in the EU?
NATAMYCIN EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NATAMYCIN do in cosmetics?
NATAMYCIN functions as: Antimicrobial, Preservative. It is classified as a cosmetic ingredient in our database. CAS number: 7681-93-8.
What is the NOAEL for NATAMYCIN?
The NOAEL (No Observed Adverse Effect Level) for NATAMYCIN is 15 mg/kg bw/day based on a Chronic study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check NATAMYCIN compliance across multiple jurisdictions:
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