Is Cuprous Iodide safe in cosmetics?
Cuprous Iodide has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Cuprous Iodide
Also known as: Copper iodide,, Copper iodide (CuI), EINECS 231-674-6, Hydro-Giene, Natural marshite (+2 more)
INCI: CUPROUS IODIDE
Cuprous Iodide (CAS 7681-65-4) is a cosmetic cosmetic ingredient functioning as Not commonly used in cosmetics; theoretical applications as antimicrobial and. Reported NOAEL =10 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 7681-65-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Cuprous Iodide is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H317, H318, H319, H335, H372, H400).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Not commonly used in cosmetics; theoretical applications as antimicrobial and deodorant agent
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
copper(1+) iodide
InChIKey
LSXDOTMGLUJQCM-UHFFFAOYSA-M
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
No FDA cosmetic-specific status; no CIR review. Not a recognized cosmetic ingredient.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cuprous Iodide.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Cuprous Iodide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =78 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =185 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Skin Eye Respiratory Irritation
Inhalation causes irritation of nose & throat. ... Contact with eyes or skin causes irritation.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Deodorizer
Stabilizing agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Cuprous Iodide.
Regulatory Flags
potential-allergen
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Cuprous Iodide by CAS number or substance name.
Studies
3
Lowest NOAEL
10 mg/kg bw/day
Highest NOAEL
185 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Copper iodide,
Copper iodide (CuI)
EINECS 231-674-6
Hydro-Giene
Natural marshite
EPA Pesticide Chemical Code 108301
UNII-7DE9CA6IL2
Chemical Function
Biocide
Deodorizer
Stabilizing agent
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
Europe; plastic_additive
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Cuprous Iodide allowed in the EU?
Cuprous Iodide EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Cuprous Iodide do in cosmetics?
Cuprous Iodide functions as: Not commonly used in cosmetics; theoretical applications as antimicrobial and deodorant agent. It is classified as a cosmetic ingredient in our database. CAS number: 7681-65-4.
What is the NOAEL for Cuprous Iodide?
The NOAEL (No Observed Adverse Effect Level) for Cuprous Iodide is =10 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Cuprous Iodide used outside cosmetics?
Cuprous Iodide also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Cuprous Iodide have different safety status in cosmetics vs industrial chemicals?
Cuprous Iodide is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H315, H317, H318, H319, H335, H372, H400).
Compliance Tools
Check Cuprous Iodide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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