Is NERYL ISOBUTYRATE safe in cosmetics?
NERYL ISOBUTYRATE has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed.
Good
Cosmetic Ingredient
NERYL ISOBUTYRATE
NERYL ISOBUTYRATE (CAS 2345-24-6) is a cosmetic cosmetic ingredient functioning as Perfuming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 2345-24-6 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[(2Z)-3,7-dimethylocta-2,6-dienyl] 2-methylpropanoate
InChIKey
OGJYXQFXLSCKTP-LCYFTJDESA-N
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
Allowed — no prohibition or restriction; FEMA GRAS designation for flavor use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 3375 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
73
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
NERYL ISOBUTYRATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | Secondary components do not raise a safety concern | TRS 913-JECFA 59/111 | FAS 40-JECFA 49/329 (1997)
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for NERYL ISOBUTYRATE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
jecfa_safe
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is NERYL ISOBUTYRATE allowed in the EU?
NERYL ISOBUTYRATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NERYL ISOBUTYRATE do in cosmetics?
NERYL ISOBUTYRATE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 2345-24-6.
Is NERYL ISOBUTYRATE used outside cosmetics?
NERYL ISOBUTYRATE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check NERYL ISOBUTYRATE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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