Nicotinamide Riboside

INCI: NIACINAMIDE RIBOSIDE CHLORIDE

CAS Number
23111-00-4 (as Nicotinamide Riboside Chloride)
Function
Skin conditioning (NAD+ precursor; cellular energy support)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not specifically restricted for cosmetic use; GRAS as dietary supplement (self-affirmed)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Limited dermal-specific safety data; cosmetic efficacy data still emerging; EFSA assessment is oral-route only.

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Concern Level: Low

Frequently Asked Questions

Is Nicotinamide Riboside safe in cosmetics?

Limited dermal-specific safety data; cosmetic efficacy data still emerging; EFSA assessment is oral-route only. The EU classifies Nicotinamide Riboside as "permitted". Safety rating: GOOD.

Is Nicotinamide Riboside allowed in the EU?

Nicotinamide Riboside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Nicotinamide Riboside do in cosmetics?

Nicotinamide Riboside functions as: Skin conditioning (NAD+ precursor; cellular energy support). It is classified as a cosmetic ingredient in our database. CAS number: 23111-00-4 (as Nicotinamide Riboside Chloride).

What is the Margin of Safety for Nicotinamide Riboside?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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