Is NITROFURAZONE safe in cosmetics?
NITROFURAZONE has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
GOOD
Cosmetic Ingredient
NITROFURAZONE
Also known as: 5-Nitro-2-furaldehyde semicarbazone, Hydrazinecarboxamide, 2-[(5-nitro-2-furanyl)methylene]-, 2-Furancarboxaldehyde, 5-nitro-,semicarbazone, Actin-N, Becafurazone (+15 more)
NITROFURAZONE (CAS 59-87-0) is a cosmetic cosmetic ingredient functioning as Antimicrobial. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Function
Antimicrobial
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
[(E)-(5-nitrofuran-2-yl)methylideneamino]urea
InChIKey
IAIWVQXQOWNYOU-FPYGCLRLSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Restricted — FDA has withdrawn approval for nitrofuran drugs in food-producing animals; not accepted for cosmetic use due to safety concerns
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
50
Evaluation Year
1989
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
124 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [31] Kligman AM (1966): https://doi.org/10.1038/jid.1966.159
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 124.14 | - | - |
| HMT | - | 0 | 620.69 | - | - |
| HMT | - | 0 | 6206.9 | - | - |
| HMT | - | 0 | 15517.24 | - | - |
| HMT | - | 0 | 31034.48 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
3, not classifiable as to its carcinogenicity to humans. (L135)
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
Nitrofural (Nitrofurazone) | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 50: (1990) Pharmaceutical Drugs
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
Nitrofurazone | TR-337: Toxicology and Carcinogenesis Studies of Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) (1988 ) | 07/14/87 | Equivocal Evidence | Clear Evidence | No Evidence | Clear Evidence | Under the conditions of these 2-year feed studies, there was equivocal evidence of carcinogenic activity of nitrofurazone for male F344/N rats as shown by the…
Source: NTP Technical Reports
Evidence for Carcinogenicity
Evaluation: There is inadequate evidence for the carcinogenicity of nitrofural in humans. There is limited evidence for the carcinogenicity of nitrofural in experimental animals. Overall evaluation: Nitrofural is not classifiable as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (1)
JECFA Evaluation
NITROFURAL | 1993 | NO ADI ALLOCATED | The Committee concluded that it could not establish an ADI for nitrofural because no-effect levels had not been established for the tumorigenic effects. Although a no-effect level (15 mg/kg bw/day) had been established in rats for testicular hypoplasia in a 13-week study, a slightly lower dose (11 mg/kg bw/day) resulted in a high incidence of testicular…
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Editorial summary
Preliminary editorial summary for NITROFURAZONE — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cosing-sourced
eu-permitted
preservative
needs-enrichment
prop65
jecfa_concern
Known Synonyms
5-Nitro-2-furaldehyde semicarbazone
Hydrazinecarboxamide, 2-[(5-nitro-2-furanyl)methylene]-
2-Furancarboxaldehyde, 5-nitro-,semicarbazone
Actin-N
Becafurazone
Biofuracina
Biofurea
BRN 0086403
Cocafurin
Dermofural
Dynazone
EINECS 200-443-1
Eldezol
Eldezol F-6
Fedacin
Flavazone
Fracine
Furacillin
Furacin-E
Furacin-HC
Chemical Function
Biocide
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
active_ingredient; Australia
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NITROFURAZONE
ChEMBL ID
CHEMBL869
Max Phase
4
Adverse Event Associations
1538
Frequently Asked Questions
Is NITROFURAZONE allowed in the EU?
NITROFURAZONE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NITROFURAZONE do in cosmetics?
NITROFURAZONE functions as: Antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 59-87-0.
Is NITROFURAZONE used outside cosmetics?
NITROFURAZONE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check NITROFURAZONE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Glucose Oxidase
EXCELLENT
Same category
Light Stabilizer; Antimicrobial (in s...
(LAVANDULA ANGUSTIFOLIA/MELISSA OFFICINALIS/HYPERICUM PERFORATUM) FLOWER/(CAMELLIA SINENSIS LEAF/(GLYCYRRHIZA GLABRA/ACANTHOPANAX SENTICOSUS) ROOT/SARRACENIA COBRA NEST LEAF/FLOWER/STALK EXTRACT
GOOD
Same category
Anti-sebum, Antimicrobial, Skin Condi...
(MAGNOLIA OFFICINALIS/PHELLODENDRON AMURENSE) BARK/CAMELLIA JAPONICA LEAF/ZINGIBER OFFICINALE ROOT/CITRUS PARADISI SEED WATER
GOOD
Same category
Anti-sebum, Antimicrobial, Antioxidan...
ACHYRANTHES JAPONICA ROOT/RHUS SEMIALATA GALL/TERMINALIA CHEBULA FRUIT/GLYCYRRHIZA URALENSIS ROOT/STEM EXTRACT
GOOD
Same category
Antimicrobial
AGASTACHE RUGOSA EXTRACT
GOOD
Same category
Antimicrobial, Antioxidant, Astringen...
AJUGA REPTANS LEAF EXTRACT
GOOD
Same category
Anti-sebum, Antimicrobial, Antioxidan...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
GOOD
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
GOOD
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
GOOD
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
GOOD
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
GOOD
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
GOOD
Similar safety
Antioxidant
Folic Acid
GOOD
Chemical family
Anti-aging; DNA synthesis/repair supp...
Galactose
EXCELLENT
Chemical family
Humectant, skin conditioning
Methotrexate
MODERATE
Chemical family
Antimetabolite / cytotoxic agent (pha...
Is NITROFURAZONE in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for NITROFURAZONE in your formulation.