Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Folic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 0.5 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1.5 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 92 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2.6 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| NOAEL | 3.8 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
| dose_tested | 50 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 0.5 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 1.5 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| dose_tested | 92 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
Emerging but formulation-challenging vitamin in cosmetics with strong rationale for anti-aging and wound healing, though severe heat and light instability necessitates opaque packaging, neutral-alkaline pH, and low-temperature manufacturing. Best used in B9+B12 combination where clinical evidence is strongest.
Regulatory Flags
Frequently Asked Questions
Is Folic Acid safe in cosmetics?
Emerging but formulation-challenging vitamin in cosmetics with strong rationale for anti-aging and wound healing, though severe heat and light instability necessitates opaque packaging, neutral-alkaline pH, and low-temperature manufacturing. Best used in B9+B12 combination where clinical evidence is strongest. The EU classifies Folic Acid as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Folic Acid allowed in the EU?
Folic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Folic Acid do in cosmetics?
Folic Acid functions as: Anti-aging; DNA synthesis/repair support; skin conditioning; wound healing. It is classified as a Active Ingredient in our database. CAS number: 59-30-3.
What is the Margin of Safety for Folic Acid?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Folic Acid?
The NOAEL (No Observed Adverse Effect Level) for Folic Acid is 50 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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