Regulatory Status
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Safety Data
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Expert Verdict
Severe - cytotoxic, teratogenic (Category X), hepatotoxic, myelosuppressive, nephrotoxic. Causes bone marrow suppression, mucositis, and potentially fatal toxicity at therapeutic doses. Absolutely no legitimate cosmetic application.. A folic acid antagonist that inhibits dihydrofolate reductase (DHFR), blocking DNA/RNA synthesis. Its appearance on this list should raise an immediate red flag - any product claiming to contain methotrexate as a "cosmetic" ingredient is either mislabeled, adulte...
Regulatory Flags
Frequently Asked Questions
Is Methotrexate safe in cosmetics?
Severe - cytotoxic, teratogenic (Category X), hepatotoxic, myelosuppressive, nephrotoxic. Causes bone marrow suppression, mucositis, and potentially fatal toxicity at therapeutic doses. Absolutely no legitimate cosmetic application.. A folic acid antagonist that inhibits dihydrofolate reductase (DHFR), blocking DNA/RNA synthesis. Its appearance on this list should raise an immediate red flag - any product claiming to contain methotrexate as a "cosmetic" ingredient is either mislabeled, adulte... The EU classifies Methotrexate as "prohibited". Safety rating: MODERATE.
Is Methotrexate allowed in the EU?
Methotrexate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methotrexate do in cosmetics?
Methotrexate functions as: Antimetabolite / cytotoxic agent (pharmaceutical - NOT a cosmetic function). It is classified as a cosmetic ingredient in our database. CAS number: 59-05-2.
What is the Margin of Safety for Methotrexate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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