Good Cosmetic Ingredient NOAEL Data GHS Classified

NONANE

CAS Number
111-84-2
Function
Perfuming
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status Permitted
🇺🇸 US Status prohibited
US Notes Allowed — not prohibited or restricted

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

4 study endpoints found for NONANE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 100 mg/kg bw/day oral mouse oral REACH
NOAEL 100 mg/kg bw/day oral rat oral REACH
NOAEL >=1000 mg/kg bw/day oral rat oral REACH
NOAEL >=1000 mg/kg bw/day oral - oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam;flame; excl mark;warn; cancer;health haz
Hazard Statements
Flammable liquid and vapour Harmful if inhaled May cause drowsiness or dizziness May be fatal if swallowed and enters airways May cause long lasting harmful effects to aquatic life
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure to the vapour could cause lowering of consciousness. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

NONANE is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions.

⚠️
Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted fragrance needs-enrichment ifra_fragrance

Frequently Asked Questions

Is NONANE safe in cosmetics?

NONANE is listed in the EU CosIng database with functions: Perfuming It is permitted in the EU without specific restrictions. The EU classifies NONANE as "Permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.

Is NONANE allowed in the EU?

NONANE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does NONANE do in cosmetics?

NONANE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 111-84-2.

What is the NOAEL for NONANE?

The NOAEL (No Observed Adverse Effect Level) for NONANE is 100 mg/kg bw/day based on a oral study via oral route in mouse. A total of 4 study endpoints are available. Source: REACH.

Is NONANE classified as hazardous under GHS?

NONANE carries a GHS signal word of "DANGER". Hazard statements: Flammable liquid and vapour Harmful if inhaled May cause drowsiness or dizziness May be fatal if swallowed and enters airways May cause long lasting harmful effects to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check NONANE compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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