Is OCTYL ACETATE safe in cosmetics?
OCTYL ACETATE has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed. 4 toxicological study endpoint(s) are available in our database.
OCTYL ACETATE
Also known as: 4-02-00-00165, BRN 1754554, EINECS 203-939-6, FEMA No. 2806, n-Octyl ethanoate (+10 more)
OCTYL ACETATE (CAS 112-14-1) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 112-14-1 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
octyl acetate
InChIKey
YLYBTZIQSIBWLI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
Allowed — GRAS (Generally Recognized As Safe) for food/flavor use; the RIFM completed an updated safety assessment in 2024 confirming safety for fragrance use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
4 study endpoints found for OCTYL ACETATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | =500 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for OCTYL ACETATE across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5184 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
Ceased manufacture
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
130
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
OCTYL ACETATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for OCTYL ACETATE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to OCTYL ACETATE by CAS number or substance name.
Studies
4
Lowest NOAEL
500 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
4-02-00-00165
BRN 1754554
EINECS 203-939-6
FEMA No. 2806
n-Octyl ethanoate
UNII-X0FN2J413S
2-Ethylhexyl acetate
Acetic acid N-octyl ester
Acetic acid octyl ester
FEMA 2806
Octanol acetate
Octyl acetate (van)
Octyl acetate, normal
Octyl ethanoate
n-Octanyl acetate
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
air; Cleaning products and household care - air freshener; detected; emissions; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OCTYL ACETATE
ChEMBL ID
CHEMBL2228456
Frequently Asked Questions
Is OCTYL ACETATE allowed in the EU?
OCTYL ACETATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OCTYL ACETATE do in cosmetics?
OCTYL ACETATE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 112-14-1.
What is the NOAEL for OCTYL ACETATE?
The NOAEL (No Observed Adverse Effect Level) for OCTYL ACETATE is 500 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Is OCTYL ACETATE used outside cosmetics?
OCTYL ACETATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check OCTYL ACETATE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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