Is HEDTA safe in cosmetics?
HEDTA has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
HEDTA
Also known as: BRN 1804795, N-(Carboxymethyl)-N'-(2-hydroxyethyl)-N,N'-ethylenediglycine, Caswell No. 487B, EINECS 205-759-3, EPA Pesticide Chemical Code 039108 (+8 more)
HEDTA (CAS 150-39-0) is a cosmetic cosmetic ingredient functioning as Chelating agent, absorbent, bulking, opacifying, viscosity controlling. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 150-39-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HEDTA is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Chelating agent, absorbent, bulking, opacifying, viscosity controlling
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
2-[2-[bis(carboxymethyl)amino]ethyl-(2-hydroxyethyl)amino]acetic acid
InChIKey
URDCARMUOSMFFI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — CIR Expert Panel concluded safe as used in cosmetic formulations (2002, reaffirmed 2019)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HEDTA.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Absorbent
Chelating agent
Filler
Opacifer
Viscosity modifier
Expert Verdict
Expert safety assessment and concern-level summary for HEDTA.
Known Synonyms
BRN 1804795
N-(Carboxymethyl)-N'-(2-hydroxyethyl)-N,N'-ethylenediglycine
Caswell No. 487B
EINECS 205-759-3
EPA Pesticide Chemical Code 039108
Hamp-ol acid
2-Hydroxyethylenediamine triacetate
N-Hydroxyethylenediaminetriacetic acid
N-Hydroxy-N,N',N'-ethylenediaminetriacetic acid trisodium salt
n-Hydroxyethylethylenediamine-n,n',n'-triacetic acid
N-(beta-Hydroxyethylethylenediamine)-N,N',N'-triacetic acid
(N-Hydroxyethylethylenedinitrilo)triacetic acid
UNII-R79J91U341
Chemical Function
Absorbent
Chelating agent
Viscosity modifier
Opacifer
Filler
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1620428
Frequently Asked Questions
Is HEDTA allowed in the EU?
HEDTA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does HEDTA do in cosmetics?
HEDTA functions as: Chelating agent, absorbent, bulking, opacifying, viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 150-39-0.
Is HEDTA used outside cosmetics?
HEDTA also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HEDTA have different safety status in cosmetics vs industrial chemicals?
HEDTA is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check HEDTA compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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