Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Disodium Succinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 180 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 5000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
OECD SIDS assessed. Readily biodegradable. Stable at pH 4–9. No eye/skin irritation data in OECD dossier — minor data gap but low concern given the chemistry (simple dicarboxylate salt). CIR concluded dicarboxylic acids and salts safe.
Regulatory Flags
Frequently Asked Questions
Is Disodium Succinate safe in cosmetics?
OECD SIDS assessed. Readily biodegradable. Stable at pH 4–9. No eye/skin irritation data in OECD dossier — minor data gap but low concern given the chemistry (simple dicarboxylate salt). CIR concluded dicarboxylic acids and salts safe. The EU classifies Disodium Succinate as "permitted". Safety rating: EXCELLENT. 4 toxicological study endpoint(s) are available in our database.
Is Disodium Succinate allowed in the EU?
Disodium Succinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Disodium Succinate do in cosmetics?
Disodium Succinate functions as: pH adjuster, buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 150-90-3.
What is the Margin of Safety for Disodium Succinate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Disodium Succinate?
The NOAEL (No Observed Adverse Effect Level) for Disodium Succinate is 500 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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