PEG-16
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for PEG-16. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1690 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 1820 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 4050 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 230 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 7500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 10900 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1128 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 25000 mg/kg bw/day | oral | mouse | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
PEG-16 is listed in the EU CosIng database with functions: Humectant, Solvent It is permitted in the EU without specific restrictions.
Regulatory Flags
Frequently Asked Questions
Is PEG-16 safe in cosmetics?
PEG-16 is listed in the EU CosIng database with functions: Humectant, Solvent It is permitted in the EU without specific restrictions. The EU classifies PEG-16 as "Permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is PEG-16 allowed in the EU?
PEG-16 EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PEG-16 do in cosmetics?
PEG-16 functions as: Humectant, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 25322-68-3.
What is the NOAEL for PEG-16?
The NOAEL (No Observed Adverse Effect Level) for PEG-16 is 1690 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check PEG-16 compliance across multiple jurisdictions:
Related Ingredients
Is PEG-16 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for PEG-16 in your formulation.