Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Diglycerin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 10000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Diglycerin is a glycerol dimer humectant assessed as safe in cosmetics at up to 28% in rinse-off and 5% in leave-on products per the 2023 CIR Final Report. Oral LD50 exceeds 5,000 mg/kg in rats and genotoxicity studies were uniformly negative.
Regulatory Flags
Frequently Asked Questions
Is Diglycerin safe in cosmetics?
Diglycerin is a glycerol dimer humectant assessed as safe in cosmetics at up to 28% in rinse-off and 5% in leave-on products per the 2023 CIR Final Report. Oral LD50 exceeds 5,000 mg/kg in rats and genotoxicity studies were uniformly negative. The EU classifies Diglycerin as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.
Is Diglycerin allowed in the EU?
Diglycerin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diglycerin do in cosmetics?
Diglycerin functions as: Humectant. It is classified as a cosmetic ingredient in our database. CAS number: 59113-36-9.
What is the Margin of Safety for Diglycerin?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diglycerin?
The NOAEL (No Observed Adverse Effect Level) for Diglycerin is 10000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.
Compliance Tools
Check Diglycerin compliance across multiple jurisdictions:
Related Ingredients
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