Glucono Delta-Lactone
INCI: GLUCONOLACTONE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Glucono Delta-Lactone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 695 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 594 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 560 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| NOAEL | 780 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
| dose_tested | 500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 695 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| dose_tested | 594 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 560 mg/kg bw/day | oral | hamster | Developmental | COSMOS_DB |
| dose_tested | 780 mg/kg bw/day | oral | rabbit | Developmental | COSMOS_DB |
Dermal Penetration Profile
Skin absorption and penetration characteristics of Glucono Delta-Lactone, relevant to systemic exposure and MoS calculations.
Source: Dermatol Surg 2004
Expert Verdict
Excellent safety profile confirmed by CIR 2022; effective polyhydroxy acid exfoliant gentler than AHAs; ECOCERT and COSMOS approved; suitable for sensitive skin
Regulatory Flags
Frequently Asked Questions
Is Glucono Delta-Lactone safe in cosmetics?
Excellent safety profile confirmed by CIR 2022; effective polyhydroxy acid exfoliant gentler than AHAs; ECOCERT and COSMOS approved; suitable for sensitive skin The EU classifies Glucono Delta-Lactone as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Glucono Delta-Lactone allowed in the EU?
Glucono Delta-Lactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glucono Delta-Lactone do in cosmetics?
Glucono Delta-Lactone functions as: pH adjuster, chelating agent, humectant, exfoliant (PHA). It is classified as a cosmetic ingredient in our database. CAS number: 90-80-2.
What is the Margin of Safety for Glucono Delta-Lactone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Glucono Delta-Lactone?
The NOAEL (No Observed Adverse Effect Level) for Glucono Delta-Lactone is 500 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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