Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for PEG-4 Methyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 4000 mg/kg bw/day | dermal | rat | dermal | REACH |
| LOAEL | 1200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 94 2104 | 1991 | rat | inhalation | REACH |
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >1000 mg/kg bw/day | dermal | code:3484 | dermal | REACH |
| NOAEL | 350 other | 1991 | rat | inhalation | REACH |
Expert Verdict
1,4-Dioxane residues present; methyl-capped terminus may modestly enhance skin penetration; limited individual toxicology data.
Regulatory Flags
Frequently Asked Questions
Is PEG-4 Methyl Ether safe in cosmetics?
1,4-Dioxane residues present; methyl-capped terminus may modestly enhance skin penetration; limited individual toxicology data. The EU classifies PEG-4 Methyl Ether as "permitted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.
Is PEG-4 Methyl Ether allowed in the EU?
PEG-4 Methyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PEG-4 Methyl Ether do in cosmetics?
PEG-4 Methyl Ether functions as: Solvent; Humectant; Film-forming; Viscosity modifier. It is classified as a cosmetic ingredient in our database. CAS number: 9004-74-4.
What is the Margin of Safety for PEG-4 Methyl Ether?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for PEG-4 Methyl Ether?
The NOAEL (No Observed Adverse Effect Level) for PEG-4 Methyl Ether is 4000 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 6 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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