Phellodendron Amurense Bark Extract

INCI: PHELLODENDRON AMURENSE BARK EXTRACT

CAS Number
164288-52-2 [^1_8]
Function
Skin conditioning, Tonic
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA permitted in cosmetics; not CIR-reviewed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Berberine content is the key concern with documented cytotoxicity at elevated concentrations; antibacterial properties are useful but pH-sensitive solubility and potential for yellow discoloration must be managed. Not recommended for oral-care products intended for ingestion without toxicology review.

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Concern Level: Moderate

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Phellodendron Amurense Bark Extract safe in cosmetics?

Berberine content is the key concern with documented cytotoxicity at elevated concentrations; antibacterial properties are useful but pH-sensitive solubility and potential for yellow discoloration must be managed. Not recommended for oral-care products intended for ingestion without toxicology review. The EU classifies Phellodendron Amurense Bark Extract as "permitted". Safety rating: MODERATE.

Is Phellodendron Amurense Bark Extract allowed in the EU?

Phellodendron Amurense Bark Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Phellodendron Amurense Bark Extract do in cosmetics?

Phellodendron Amurense Bark Extract functions as: Skin conditioning, Tonic. It is classified as a cosmetic ingredient in our database. CAS number: 164288-52-2 [^1_8].

What is the Margin of Safety for Phellodendron Amurense Bark Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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