Is Phenethyl 2-Methylbutyrate safe in cosmetics?
Phenethyl 2-Methylbutyrate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Phenethyl 2-Methylbutyrate
Also known as: FEMA 3632, Butanoic acid, 2-methyl-, 2-phenylethyl ester, Benzylcarbinyl 2-methylbutyrate, BRN 2266397, Butyric acid, 2-methyl-, phenethyl ester (+6 more)
INCI: PHENETHYL 2-METHYLBUTYRATE
Phenethyl 2-Methylbutyrate (CAS 24817-51-4) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 24817-51-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-phenylethyl 2-methylbutanoate
InChIKey
KVKKTLBBYFABAZ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically regulated; FEMA GRAS for food flavoring
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenethyl 2-Methylbutyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
993
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BENZYLCARBINYL 2-METHYLBUTYRATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PHENETHYL 2-METHYLBUTYRATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
beta-PHENETHYL alpha-METHYLBUTANOATE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Phenethyl 2-Methylbutyrate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
FEMA 3632
Butanoic acid, 2-methyl-, 2-phenylethyl ester
Benzylcarbinyl 2-methylbutyrate
BRN 2266397
Butyric acid, 2-methyl-, phenethyl ester
EINECS 246-476-5
FEMA No. 3632
beta-Phenethyl alpha-methylbutanoate
beta-Phenylethyl alpha-methylbutanoate
Phenylethyl 2-methylbutyrate
UNII-4D2I5SJ45Q
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183389
Frequently Asked Questions
Is Phenethyl 2-Methylbutyrate allowed in the EU?
Phenethyl 2-Methylbutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenethyl 2-Methylbutyrate do in cosmetics?
Phenethyl 2-Methylbutyrate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 24817-51-4.
Is Phenethyl 2-Methylbutyrate used outside cosmetics?
Phenethyl 2-Methylbutyrate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phenethyl 2-Methylbutyrate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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