Phloretin

INCI: PHLORETIN

CAS Number
60-82-2 [^1_9]
Function
Antioxidant, anti-sebum; enhances skin penetration of other actives
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA permitted; CIR has not published a dedicated review; widely used in commercial products (e.g., SkinCeuticals)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

SDS classifies as irritant to skin and mucous membranes; acts as a penetration enhancer with potential formulation-level interactions; oxidatively unstable and requires antioxidant stabilization such as ferulic acid and vitamin C systems.

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Concern Level: Low

Regulatory Flags

endocrine_disruptor

Frequently Asked Questions

Is Phloretin safe in cosmetics?

SDS classifies as irritant to skin and mucous membranes; acts as a penetration enhancer with potential formulation-level interactions; oxidatively unstable and requires antioxidant stabilization such as ferulic acid and vitamin C systems. The EU classifies Phloretin as "permitted". Safety rating: GOOD.

Is Phloretin allowed in the EU?

Phloretin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Phloretin do in cosmetics?

Phloretin functions as: Antioxidant, anti-sebum; enhances skin penetration of other actives. It is classified as a cosmetic ingredient in our database. CAS number: 60-82-2 [^1_9].

What is the Margin of Safety for Phloretin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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