Moderate Cosmetic Ingredient

Phytonadione Epoxide

INCI: PHYTONADIONE EPOXIDE

CAS Number
25486-55-9 (EC No. 247-022-9)
Function
Skin conditioning agent for reducing dark circles, redness, and improving skin tone
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically restricted by FDA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Rising allergic contact dermatitis cases with photoinduced reactions reported; predecessor phytonadione (vitamin K1) was banned in EU cosmetics in 2009 due to identical sensitization concerns, suggesting high likelihood of future EU restriction.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Phytonadione Epoxide safe in cosmetics?

Rising allergic contact dermatitis cases with photoinduced reactions reported; predecessor phytonadione (vitamin K1) was banned in EU cosmetics in 2009 due to identical sensitization concerns, suggesting high likelihood of future EU restriction. The EU classifies Phytonadione Epoxide as "permitted". Safety rating: MODERATE.

Is Phytonadione Epoxide allowed in the EU?

Phytonadione Epoxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Phytonadione Epoxide do in cosmetics?

Phytonadione Epoxide functions as: Skin conditioning agent for reducing dark circles, redness, and improving skin tone. It is classified as a cosmetic ingredient in our database. CAS number: 25486-55-9 (EC No. 247-022-9).

What is the Margin of Safety for Phytonadione Epoxide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Phytonadione Epoxide compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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