Picolinamide

INCI: PICOLINAMIDE

CAS Number
1452-77-3
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically regulated; SDS advises against food/drug/biocide use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

GHS H315 (skin irritant), H319 (serious eye irritant), H335 (respiratory irritant); not niacinamide—do NOT confuse with nicotinamide (pyridine-3-carboxamide); positional isomer only

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Concern Level: Moderate

Frequently Asked Questions

Is Picolinamide safe in cosmetics?

GHS H315 (skin irritant), H319 (serious eye irritant), H335 (respiratory irritant); not niacinamide—do NOT confuse with nicotinamide (pyridine-3-carboxamide); positional isomer only The EU classifies Picolinamide as "permitted". Safety rating: MODERATE.

Is Picolinamide allowed in the EU?

Picolinamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Picolinamide do in cosmetics?

Picolinamide functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 1452-77-3.

What is the Margin of Safety for Picolinamide?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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