Is Piperlonguminine safe in cosmetics?
Piperlonguminine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Piperlonguminine
Also known as: N-Isobutylpiperamide, 2,4-Pentadienamide, 5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-, (E,E)-, 2,4-Pentadienamide, 5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-, (2E,4E)-
INCI: PIPERLONGUMININE
Piperlonguminine (CAS 5950-12-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning; anti-inflammatory alkaloid amide. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 5950-12-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; anti-inflammatory alkaloid amide
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)penta-2,4-dienamide
InChIKey
WHAAPCGHVWVUEX-GGWOSOGESA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically listed by FDA for cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Piperlonguminine.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Biocide
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Piperlonguminine.
Known Synonyms
N-Isobutylpiperamide
2,4-Pentadienamide, 5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-, (E,E)-
2,4-Pentadienamide, 5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-, (2E,4E)-
Chemical Function
Biocide
Antioxidant
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PIPERLONGUMININE
ChEMBL ID
CHEMBL253973
Frequently Asked Questions
Is Piperlonguminine allowed in the EU?
Piperlonguminine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Piperlonguminine do in cosmetics?
Piperlonguminine functions as: Skin conditioning; anti-inflammatory alkaloid amide. It is classified as a cosmetic ingredient in our database. CAS number: 5950-12-9.
Is Piperlonguminine used outside cosmetics?
Piperlonguminine also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Piperlonguminine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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