Poloxamer 188 Succinate

INCI: POLOXAMER 188 SUCCINATE

CAS Number
Not assigned
Function
Skin conditioning agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not independently CIR-reviewed; derivative of CIR-assessed Poloxamer 188

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

No independent CIR or SCCS safety assessment; succinic acid ester hydrolysis and residual EO/PO/1,4-dioxane impurities from parent Poloxamer 188 require evaluation.

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Concern Level: Moderate

Frequently Asked Questions

Is Poloxamer 188 Succinate safe in cosmetics?

No independent CIR or SCCS safety assessment; succinic acid ester hydrolysis and residual EO/PO/1,4-dioxane impurities from parent Poloxamer 188 require evaluation. The EU classifies Poloxamer 188 Succinate as "permitted". Safety rating: MODERATE.

Is Poloxamer 188 Succinate allowed in the EU?

Poloxamer 188 Succinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Poloxamer 188 Succinate do in cosmetics?

Poloxamer 188 Succinate functions as: Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for Poloxamer 188 Succinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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