Poloxamer 288

INCI: POLOXAMER 288

CAS Number
9003-11-6 (generic)
Function
Surfactant – cleansing, surfactant – emulsifying, solubilizing agent
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR: safe as used (2008); FDA indirect food additive

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Trace 1,4-dioxane/EO/PO impurities (standard ethoxylation concern); high MW provides excellent safety margin. Minimal cosmetic use history reported.

⚠️
Concern Level: None

Frequently Asked Questions

Is Poloxamer 288 safe in cosmetics?

Trace 1,4-dioxane/EO/PO impurities (standard ethoxylation concern); high MW provides excellent safety margin. Minimal cosmetic use history reported. The EU classifies Poloxamer 288 as "permitted". Safety rating: EXCELLENT.

Is Poloxamer 288 allowed in the EU?

Poloxamer 288 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Poloxamer 288 do in cosmetics?

Poloxamer 288 functions as: Surfactant – cleansing, surfactant – emulsifying, solubilizing agent. It is classified as a cosmetic ingredient in our database. CAS number: 9003-11-6 (generic).

What is the Margin of Safety for Poloxamer 288?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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