Poloxamine 1501

INCI: POLOXAMINE 1501

CAS Number
11111-34-5
Function
Surfactant – Cleansing; Surfactant – Emulsifying
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No specific FDA monograph; no CIR assessment

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

High PO block weight with most lipophilic profile among Poloxamines; potential 1,4-dioxane and ethylene oxide residuals present; extremely limited use data and no dedicated safety monograph.

⚠️
Concern Level: Moderate

Regulatory Flags

ifra_fragrance

Frequently Asked Questions

Is Poloxamine 1501 safe in cosmetics?

High PO block weight with most lipophilic profile among Poloxamines; potential 1,4-dioxane and ethylene oxide residuals present; extremely limited use data and no dedicated safety monograph. The EU classifies Poloxamine 1501 as "permitted". Safety rating: MODERATE.

Is Poloxamine 1501 allowed in the EU?

Poloxamine 1501 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Poloxamine 1501 do in cosmetics?

Poloxamine 1501 functions as: Surfactant – Cleansing; Surfactant – Emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 11111-34-5.

What is the Margin of Safety for Poloxamine 1501?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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