Poloxamine 504

INCI: POLOXAMINE 504

CAS Number
11111-34-5
Function
Surfactant – emulsifying, dispersant, solubilizer
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically restricted by FDA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Impurity control for EO/PO residuals and 1,4-dioxane required

⚠️
Concern Level: Moderate

Regulatory Flags

ifra_fragrance

Frequently Asked Questions

Is Poloxamine 504 safe in cosmetics?

Impurity control for EO/PO residuals and 1,4-dioxane required The EU classifies Poloxamine 504 as "permitted". Safety rating: MODERATE.

Is Poloxamine 504 allowed in the EU?

Poloxamine 504 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Poloxamine 504 do in cosmetics?

Poloxamine 504 functions as: Surfactant – emulsifying, dispersant, solubilizer. It is classified as a cosmetic ingredient in our database. CAS number: 11111-34-5.

What is the Margin of Safety for Poloxamine 504?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

📱

Is Poloxamine 504 in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Poloxamine 504 in your formulation.