Polyglyceryl-2 Oleate

INCI: POLYGLYCERYL-2 OLEATE

CAS Number
49553-76-6 / 9007-48-1 (generic)
Function
Skin-conditioning agent – emollient; surfactant – emulsifying agent
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR: Safe as used (2016/2023); FDA-approved as inactive ingredient in drug products (Polyglyceryl-3 Oleate approved in topical, oral, vaginal drugs)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

At elevated concentrations, may enhance penetration of other actives as demonstrated with related polyglyceryl esters. GRAS status for food use.

⚠️
Concern Level: None

Frequently Asked Questions

Is Polyglyceryl-2 Oleate safe in cosmetics?

At elevated concentrations, may enhance penetration of other actives as demonstrated with related polyglyceryl esters. GRAS status for food use. The EU classifies Polyglyceryl-2 Oleate as "permitted". Safety rating: EXCELLENT.

Is Polyglyceryl-2 Oleate allowed in the EU?

Polyglyceryl-2 Oleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polyglyceryl-2 Oleate do in cosmetics?

Polyglyceryl-2 Oleate functions as: Skin-conditioning agent – emollient; surfactant – emulsifying agent. It is classified as a cosmetic ingredient in our database. CAS number: 49553-76-6 / 9007-48-1 (generic).

What is the Margin of Safety for Polyglyceryl-2 Oleate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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