Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for PPG-4 Butyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 other | oral | rat | oral | REACH |
| NOEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 other | oral | rat | oral | REACH |
| NOAEL | 1000 other | oral | rat | oral | REACH |
Expert Verdict
Formulate to avoid irritation — toxicity data indicate irritation potential at higher concentrations; lower MW PPG butyl ethers show higher toxicity than higher MW homologs
Regulatory Flags
Frequently Asked Questions
Is PPG-4 Butyl Ether safe in cosmetics?
Formulate to avoid irritation — toxicity data indicate irritation potential at higher concentrations; lower MW PPG butyl ethers show higher toxicity than higher MW homologs The EU classifies PPG-4 Butyl Ether as "restricted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.
Is PPG-4 Butyl Ether allowed in the EU?
PPG-4 Butyl Ether EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does PPG-4 Butyl Ether do in cosmetics?
PPG-4 Butyl Ether functions as: Skin conditioning agent, hair conditioning agent, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 9003-13-8.
What is the Margin of Safety for PPG-4 Butyl Ether?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for PPG-4 Butyl Ether?
The NOAEL (No Observed Adverse Effect Level) for PPG-4 Butyl Ether is 1000 other based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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