Is PPG-40 Butyl Ether safe in cosmetics?
PPG-40 Butyl Ether has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
PPG-40 Butyl Ether
Also known as: Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-butyl-.omega.-hydroxy-, Poly(oxy(methyl-1,2-ethanediyl)),alpha-butyl-omega-hydroxy-, Polyoxypropylene monobutyl ether, Butoxypolypropylene glycol, Ambiflo L-317 (+14 more)
INCI: PPG-40 BUTYL ETHER
PPG-40 Butyl Ether (CAS 9003-13-8) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent; Hair conditioning agent; Solvent. Reported NOAEL =10 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 9003-13-8 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent; Hair conditioning agent; Solvent
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR-reviewed — safe for use in cosmetics when formulated to avoid irritation. Used at concentrations up to 60.5% in leave-on products
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for PPG-40 Butyl Ether.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for PPG-40 Butyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | dermal | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =30 mg/kg bw/day | dermal | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =50 mg/kg bw/day | oral | Rabbit | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =80 mg/kg bw/day | dermal | Rat | acute | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | dermal | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =115 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =150 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =350 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =450 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Softener and conditioner
Solvent
Surfactant (surface active agent)
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for PPG-40 Butyl Ether.
Regulatory Flags
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to PPG-40 Butyl Ether by CAS number or substance name.
Studies
11
Lowest NOAEL
10 mg/kg bw/day
Highest NOAEL
600 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-butyl-.omega.-hydroxy-
Poly(oxy(methyl-1,2-ethanediyl)),alpha-butyl-omega-hydroxy-
Polyoxypropylene monobutyl ether
Butoxypolypropylene glycol
Ambiflo L-317
Butoxy polypropylene glycol
Butoxypolypropylene glycol 400
Butoxypolypropylene glycol 800
Butoxypropanediol polymer
Caswell No. 122
Crag fly repellent
EPA Pesticide Chemical Code 011901
Exp. miticide No. 7
Newpol LB3000
Polyoxypropylene(40) butyl ether
Polypropylene glycol monobutylether
Poly(propylene oxide), monobutyl ether
Stabilene
Stabilene fly repellent
Chemical Function
Solvent
Softener and conditioner
Regulatory Lists
Indirect additives food contact (10/2018)
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is PPG-40 Butyl Ether allowed in the EU?
PPG-40 Butyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PPG-40 Butyl Ether do in cosmetics?
PPG-40 Butyl Ether functions as: Skin conditioning agent; Hair conditioning agent; Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 9003-13-8.
What is the NOAEL for PPG-40 Butyl Ether?
The NOAEL (No Observed Adverse Effect Level) for PPG-40 Butyl Ether is =10 mg/kg bw/day based on a reproduction developmental study via dermal route in Rat. A total of 10 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is PPG-40 Butyl Ether used outside cosmetics?
PPG-40 Butyl Ether also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check PPG-40 Butyl Ether compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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