Good Cosmetic Ingredient NOAEL Data

Propanediol Dicaprylate/Caprate

INCI: PROPANEDIOL DICAPRYLATE/CAPRATE

CAS Number
1072005-10-7
Function
Skin Conditioning — Emollient
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not restricted; permitted in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Propanediol Dicaprylate/Caprate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=1000 mg/kg bw/day oral rat oral REACH
NOEL >=1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

CIR grouped review (Monoalkylglycol Dialkyl Acid Esters, 2017) — Panel had irritation data and sensitization data on file . Synthetic/plant origin .

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen natural-origin

Frequently Asked Questions

Is Propanediol Dicaprylate/Caprate safe in cosmetics?

CIR grouped review (Monoalkylglycol Dialkyl Acid Esters, 2017) — Panel had irritation data and sensitization data on file . Synthetic/plant origin . The EU classifies Propanediol Dicaprylate/Caprate as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Propanediol Dicaprylate/Caprate allowed in the EU?

Propanediol Dicaprylate/Caprate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Propanediol Dicaprylate/Caprate do in cosmetics?

Propanediol Dicaprylate/Caprate functions as: Skin Conditioning — Emollient. It is classified as a cosmetic ingredient in our database. CAS number: 1072005-10-7.

What is the Margin of Safety for Propanediol Dicaprylate/Caprate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Propanediol Dicaprylate/Caprate?

The NOAEL (No Observed Adverse Effect Level) for Propanediol Dicaprylate/Caprate is >=1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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