Is Propolis Extract safe in cosmetics?
Propolis Extract has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Propolis Extract
INCI: PROPOLIS EXTRACT
Propolis Extract (CAS 85665-41-4) is a cosmetic cosmetic ingredient functioning as Anti-inflammatory via NF-κB inhibition by caffeic acid phenethyl ester (CAPE),. EU Regulation 1223/2009 status: permitted, max 10%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 85665-41-4 →
Auto-generated CPSR Part A draft with source citations
Function
Anti-inflammatory via NF-κB inhibition by caffeic acid phenethyl ester (CAPE), antimicrobial, antioxidant
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
EU Max Conc.
10%
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Propolis Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "85665-41-4", "anti_acne_mechanism": "antibacterial/anti_inflammatory", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "p_acnes_mic_ug_per_ml": "100-500", "sebum_reduction_pct_clinical": "5-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functi…
anti_pollution
{"cas_number": "9009-62-5", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulatio…
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "5.0", "typical_concentration_pct": "2.0", "product_type": "Moisturizer", "function_at_concentration": "Antimicrobial, healing", "source": "Clinical literature"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "45", "estimated_cost_per_kg_usd_high": "85", "natural_premium_markup_pct": "65", "organic_certified_premium_pct": "110", "supply_chain_volatility": "medium", "primary_source_region": "Brazil/New Zealand", "synthetic_vs_natural_cost_ratio": "2.5", "bulk_discount_threshold_kg": "50", "seasonal_price_variation": "medium", "commodity_or_spec…
deodorant
{"cas_number": "9009-62-5", "ingredient_class": "antimicrobial_deodorant", "mechanism_of_action": "bacterial_growth_inhibition", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "8-12", "odor_reduction_pct": "45-65", "bacteriostatic": "yes", "bactericidal": "yes", "target_bacteria": "broad_spectrum", "microbiome_impact": "selective", "axillary_microbiome_effect": "va…
depigmentation
{"cas_number": "9009-62-5", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Honey/bee product with enzymatic and antioxidant brightening", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-3…
microbiome_impact
{"microbiome_effect": "mixed", "prebiotic": "yes", "probiotic_compatible": "limited", "antimicrobial_spectrum": "selective", "preservative_effect_on_microbiome": "Bee product; antimicrobial; antioxidant; moderate selectivity", "skin_flora_disruption": "mild", "gut_microbiome_risk": "low", "microbiome_recovery_time": "5-7 days", "selective_antimicrobial": "yes", "beneficial_bacteria_support": "S. e…
pediatric_safety
{"safe_for_newborn_0_6m": "caution", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "5.0", "adult_max_concentration_pct": "5.0", "pediatric_dermal_absorption_factor": "normal", "immature_skin_barrier_risk": "low", "oral_ingestion_risk": "low", "diaper_area_safe": "yes", "pediatric_alle…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Regulatory List Membership (1)
EU Regulated in Personal Care
Expert Verdict
Expert safety assessment and concern-level summary for Propolis Extract.
Regulatory Flags
Sensitizer
Chemical Function
Softener and conditioner
Humectant
Pharmaceutical
Regulatory Lists
Europe
Personal care
Europe
Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Propolis Extract allowed in the EU?
Propolis Extract EU regulatory status: permitted. Maximum allowed concentration: 10%. This is based on EU Regulation 1223/2009 and its amendments.
What does Propolis Extract do in cosmetics?
Propolis Extract functions as: Anti-inflammatory via NF-κB inhibition by caffeic acid phenethyl ester (CAPE), antimicrobial, antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 85665-41-4.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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