PROTEASE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for PROTEASE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 5000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 5000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
Expert Verdict
PROTEASE is listed in the EU CosIng database with functions: Skin Conditioning It is permitted in the EU without specific restrictions.
Regulatory Flags
Frequently Asked Questions
Is PROTEASE safe in cosmetics?
PROTEASE is listed in the EU CosIng database with functions: Skin Conditioning It is permitted in the EU without specific restrictions. The EU classifies PROTEASE as "Permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is PROTEASE allowed in the EU?
PROTEASE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PROTEASE do in cosmetics?
PROTEASE functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 9001-92-7.
What is the NOAEL for PROTEASE?
The NOAEL (No Observed Adverse Effect Level) for PROTEASE is 1000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check PROTEASE compliance across multiple jurisdictions:
Related Ingredients
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