Moderate Cosmetic Ingredient NOAEL Data

Propylene Glycol Dibenzoate

INCI: PROPYLENE GLYCOL DIBENZOATE

CAS Number
19224-26-1
Function
Skin-conditioning agent; plasticizer; also used as a flavoring agent (JECFA-evaluated)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes JECFA evaluated (2002) โ€” "no safety concern at current levels of intake when used as a flavouring agent"; also used in cosmetics without FDA restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Propylene Glycol Dibenzoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 2541 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

โš  Do NOT confuse with di(propylene glycol) dibenzoate (CAS 27138-31-4), which has reproductive toxicity (Cat. 2) and aspiration hazard flags . โš  Ensure cosmetic-grade purity โ€” industrial plasticizer grades may contain impurities not acceptable for cosmetic use

โš ๏ธ
Concern Level: High

Regulatory Flags

ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Propylene Glycol Dibenzoate safe in cosmetics?

โš  Do NOT confuse with di(propylene glycol) dibenzoate (CAS 27138-31-4), which has reproductive toxicity (Cat. 2) and aspiration hazard flags . โš  Ensure cosmetic-grade purity โ€” industrial plasticizer grades may contain impurities not acceptable for cosmetic use The EU classifies Propylene Glycol Dibenzoate as "permitted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Propylene Glycol Dibenzoate allowed in the EU?

Propylene Glycol Dibenzoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Propylene Glycol Dibenzoate do in cosmetics?

Propylene Glycol Dibenzoate functions as: Skin-conditioning agent; plasticizer; also used as a flavoring agent (JECFA-evaluated). It is classified as a cosmetic ingredient in our database. CAS number: 19224-26-1.

What is the Margin of Safety for Propylene Glycol Dibenzoate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Propylene Glycol Dibenzoate?

The NOAEL (No Observed Adverse Effect Level) for Propylene Glycol Dibenzoate is 2541 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

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