Regulatory Status
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Safety Data
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Expert Verdict
🔴 GHS-classified skin and respiratory sensitizer . Known to cause anaphylaxis via injection (pharmaceutical use). Fish-derived (salmon) — allergen disclosure required. NOT for use in aerosolized or spray products. IARC: no carcinogenicity concern
Regulatory Flags
Frequently Asked Questions
Is Protamine Sulfate safe in cosmetics?
🔴 GHS-classified skin and respiratory sensitizer . Known to cause anaphylaxis via injection (pharmaceutical use). Fish-derived (salmon) — allergen disclosure required. NOT for use in aerosolized or spray products. IARC: no carcinogenicity concern The EU classifies Protamine Sulfate as "permitted". Safety rating: MODERATE.
Is Protamine Sulfate allowed in the EU?
Protamine Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Protamine Sulfate do in cosmetics?
Protamine Sulfate functions as: Skin conditioning, hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 9009-65-8 (from salmon sperm) / 53597-25-4 (synthetic).
What is the Margin of Safety for Protamine Sulfate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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