Excellent Antioxidant NOAEL Data

Catalase

INCI: CATALASE

CAS Number
9001-05-2
Function
Enzymatic antioxidant; preventive antioxidant; converts hydrogen peroxide (H₂O₂) to water and oxygen; protects cells from oxidative damage at the initiation stage
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No dedicated CIR safety assessment. FDA recognizes catalase as GRAS for food use under 21 CFR 184. No FDA restriction on cosmetic use.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Catalase. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

CAS 9001-05-2. EU: Not restricted under EC 1223/2009; freely permitted. US: No CIR monograph; FDA GRAS for food enzyme preparations (21 CFR 184); no cosmetic restriction.

⚠️
Concern Level: None

Regulatory Flags

endogenous-enzyme antioxidant hydrogen-peroxide-neutralizer high-molecular-weight no-systemic-absorption natural-origin eu_banned_cosmetics epa_safer_alternative eu_cosing_listed

Frequently Asked Questions

Is Catalase safe in cosmetics?

CAS 9001-05-2. EU: Not restricted under EC 1223/2009; freely permitted. US: No CIR monograph; FDA GRAS for food enzyme preparations (21 CFR 184); no cosmetic restriction. The EU classifies Catalase as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.

Is Catalase allowed in the EU?

Catalase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Catalase do in cosmetics?

Catalase functions as: Enzymatic antioxidant; preventive antioxidant; converts hydrogen peroxide (H₂O₂) to water and oxygen; protects cells from oxidative damage at the initiation stage. It is classified as a Antioxidant in our database. CAS number: 9001-05-2.

What is the Margin of Safety for Catalase?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Catalase?

The NOAEL (No Observed Adverse Effect Level) for Catalase is 1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

Compliance Tools

Check Catalase compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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