Pueraria Mirifica Root Extract

INCI: PUERARIA MIRIFICA ROOT EXTRACT

CAS Number
Not assigned (CosIng Ref No. 58700)
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted under general cosmetic ingredient provisions; FDA has issued warnings for dietary supplement forms but not cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

🔴 Strongest phytoestrogen in this list. Miroestrol, deoxymiroestrol, and isoflavones collectively exert significant estrogenic activity . Preferential ER-β binding documented but ER-α cross-activity cannot be excluded at higher concentrations . Thai regulatory framework restricts oral doses. For cosmetics: use at lowest effective concentration, exclude from products for children/pregnant women, include endocrine safety data in safety dossier

⚠️
Concern Level: Moderate

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Pueraria Mirifica Root Extract safe in cosmetics?

🔴 Strongest phytoestrogen in this list. Miroestrol, deoxymiroestrol, and isoflavones collectively exert significant estrogenic activity . Preferential ER-β binding documented but ER-α cross-activity cannot be excluded at higher concentrations . Thai regulatory framework restricts oral doses. For cosmetics: use at lowest effective concentration, exclude from products for children/pregnant women, include endocrine safety data in safety dossier The EU classifies Pueraria Mirifica Root Extract as "permitted". Safety rating: MODERATE.

Is Pueraria Mirifica Root Extract allowed in the EU?

Pueraria Mirifica Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pueraria Mirifica Root Extract do in cosmetics?

Pueraria Mirifica Root Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (CosIng Ref No. 58700).

What is the Margin of Safety for Pueraria Mirifica Root Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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