Poor Cosmetic Ingredient GHS Classified

PVP-Iodine

INCI: PVP-IODINE (POVIDONE-IODINE) [^1_18]

CAS Number
25655-41-8
Function
Antimicrobial, antiseptic (primarily pharmaceutical, not cosmetic) [^1_18]
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA-approved OTC antiseptic drug; not a standard cosmetic ingredient [^1_18][^1_20]

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis.

Expert Verdict

Critical: ECHA BPC classified as endocrine disruptor; not approved for cosmetic use in EU; thyroid disruption via dermal absorption; restricted to medical/biocidal applications [^1_21][^1_19]

โš ๏ธ
Concern Level: High

Frequently Asked Questions

Is PVP-Iodine safe in cosmetics?

Critical: ECHA BPC classified as endocrine disruptor; not approved for cosmetic use in EU; thyroid disruption via dermal absorption; restricted to medical/biocidal applications [^1_21][^1_19] The EU classifies PVP-Iodine as "permitted". Safety rating: POOR.

Is PVP-Iodine allowed in the EU?

PVP-Iodine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does PVP-Iodine do in cosmetics?

PVP-Iodine functions as: Antimicrobial, antiseptic (primarily pharmaceutical, not cosmetic) [^1_18]. It is classified as a cosmetic ingredient in our database. CAS number: 25655-41-8.

What is the Margin of Safety for PVP-Iodine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is PVP-Iodine in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for PVP-Iodine in your formulation.