Pyridoxal 5-Phosphate

INCI: PYRIDOXAL 5-PHOSPHATE

CAS Number
54-47-7 [^1_10]
Function
Skin conditioning (active form of Vitamin B6)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes GRAS as dietary supplement; permitted in cosmetics under general provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Stability concerns โ€” light-sensitive and pH-sensitive; degrades in formulation if not properly stabilized [^1_10]

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Concern Level: Low

Frequently Asked Questions

Is Pyridoxal 5-Phosphate safe in cosmetics?

Stability concerns โ€” light-sensitive and pH-sensitive; degrades in formulation if not properly stabilized [^1_10] The EU classifies Pyridoxal 5-Phosphate as "permitted". Safety rating: GOOD.

Is Pyridoxal 5-Phosphate allowed in the EU?

Pyridoxal 5-Phosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pyridoxal 5-Phosphate do in cosmetics?

Pyridoxal 5-Phosphate functions as: Skin conditioning (active form of Vitamin B6). It is classified as a cosmetic ingredient in our database. CAS number: 54-47-7 [^1_10].

What is the Margin of Safety for Pyridoxal 5-Phosphate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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