Is Quaternium-45 safe in cosmetics?
Quaternium-45 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Quaternium-45
Also known as: 2-(3,4-Dimethyl-1,3-oxazol-2(3H)-ylidene)-N-phenylethan-1-imine--hydrogen iodide (1/1), EINECS 244-158-0, Kankohso 401
INCI: QUATERNIUM-45
Quaternium-45 (CAS 21034-17-3) is a cosmetic cosmetic ingredient functioning as Antistatic. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 21034-17-3 →
Auto-generated CPSR Part A draft with source citations
Function
Antistatic
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
N-[(E)-2-(3,4-dimethyl-1,3-oxazol-3-ium-2-yl)ethenyl]aniline iodide
InChIKey
MAQWKZSXWNXMPC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; historically also known as Sensitizer/Photosensitizer 401 (photographic chemical crossover)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Quaternium-45.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Expert Verdict
Expert safety assessment and concern-level summary for Quaternium-45.
Regulatory Flags
potential-allergen
Known Synonyms
2-(3,4-Dimethyl-1,3-oxazol-2(3H)-ylidene)-N-phenylethan-1-imine--hydrogen iodide (1/1)
EINECS 244-158-0
Kankohso 401
Chemical Function
Anti-static agent
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Frequently Asked Questions
Is Quaternium-45 allowed in the EU?
Quaternium-45 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Quaternium-45 do in cosmetics?
Quaternium-45 functions as: Antistatic. It is classified as a cosmetic ingredient in our database. CAS number: 21034-17-3.
Compliance Tools
Check Quaternium-45 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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