Quinine

INCI: QUININE

CAS Number
130-95-0
Function
Denaturant (for alcohol denaturation in cosmetics); also has tonic/bittering properties
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted for cosmetic use; primarily used as a denaturant for SD Alcohol formulations; no specific cosmetic ban

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Photosensitizer; systemic toxicity risk if absorbed in significant quantities (thrombocytopenia reported with oral use); subject to strict concentration limits in the EU

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Concern Level: High

Regulatory Flags

potential-allergen eu_cosing_listed

Frequently Asked Questions

Is Quinine safe in cosmetics?

Photosensitizer; systemic toxicity risk if absorbed in significant quantities (thrombocytopenia reported with oral use); subject to strict concentration limits in the EU The EU classifies Quinine as "restricted". Safety rating: MODERATE.

Is Quinine allowed in the EU?

Quinine EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Quinine do in cosmetics?

Quinine functions as: Denaturant (for alcohol denaturation in cosmetics); also has tonic/bittering properties. It is classified as a cosmetic ingredient in our database. CAS number: 130-95-0.

What is the Margin of Safety for Quinine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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