Retinoyl Oligopeptide-161

INCI: RETINOYL OLIGOPEPTIDE-161

CAS Number
Not publicly assigned/available
Function
Skin conditioning (anti-aging peptide conjugate) [^1_1]
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific monograph; permitted as cosmetic ingredient (not reviewed by CIR)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Novel ingredient with no independent safety review; retinoyl moiety may release retinoid activity โ€” requires stability and irritation testing in formulation [^1_1]

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Concern Level: Moderate

Frequently Asked Questions

Is Retinoyl Oligopeptide-161 safe in cosmetics?

Novel ingredient with no independent safety review; retinoyl moiety may release retinoid activity โ€” requires stability and irritation testing in formulation [^1_1] The EU classifies Retinoyl Oligopeptide-161 as "permitted". Safety rating: MODERATE.

Is Retinoyl Oligopeptide-161 allowed in the EU?

Retinoyl Oligopeptide-161 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Retinoyl Oligopeptide-161 do in cosmetics?

Retinoyl Oligopeptide-161 functions as: Skin conditioning (anti-aging peptide conjugate) [^1_1]. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned/available.

What is the Margin of Safety for Retinoyl Oligopeptide-161?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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