Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Pentapeptide-4 parent (KTTKS) has poor skin penetration alone [^1_3]; conjugation with retinoyl may alter delivery — no studies confirm safety of this specific conjugate
Frequently Asked Questions
Is Retinoyl Pentapeptide-4 safe in cosmetics?
Pentapeptide-4 parent (KTTKS) has poor skin penetration alone [^1_3]; conjugation with retinoyl may alter delivery — no studies confirm safety of this specific conjugate The EU classifies Retinoyl Pentapeptide-4 as "permitted". Safety rating: MODERATE.
Is Retinoyl Pentapeptide-4 allowed in the EU?
Retinoyl Pentapeptide-4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Retinoyl Pentapeptide-4 do in cosmetics?
Retinoyl Pentapeptide-4 functions as: Skin conditioning; anti-aging (retinoid + pentapeptide-4 collagen-stimulating moiety) [^1_3]. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned/available.
What is the Margin of Safety for Retinoyl Pentapeptide-4?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Retinoyl Pentapeptide-4 compliance across multiple jurisdictions:
Related Ingredients
Is Retinoyl Pentapeptide-4 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Retinoyl Pentapeptide-4 in your formulation.