Retinyl Dimethylglycylprolinate

INCI: RETINYL DIMETHYLGLYCYLPROLINATE

CAS Number
Not publicly assigned/available
Function
Skin conditioning (retinyl ester of amino acid derivative — designed as a gentler retinoid delivery form)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No specific monograph; permitted as cosmetic ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Key concern: does it convert to retinol in vivo? If yes, the EU Annex III/376 Vitamin A restrictions may apply by analogy. No SCCS opinion exists. Manufacturers should provide retinol equivalent conversion data

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Concern Level: Moderate

Frequently Asked Questions

Is Retinyl Dimethylglycylprolinate safe in cosmetics?

Key concern: does it convert to retinol in vivo? If yes, the EU Annex III/376 Vitamin A restrictions may apply by analogy. No SCCS opinion exists. Manufacturers should provide retinol equivalent conversion data The EU classifies Retinyl Dimethylglycylprolinate as "permitted". Safety rating: MODERATE.

Is Retinyl Dimethylglycylprolinate allowed in the EU?

Retinyl Dimethylglycylprolinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Retinyl Dimethylglycylprolinate do in cosmetics?

Retinyl Dimethylglycylprolinate functions as: Skin conditioning (retinyl ester of amino acid derivative — designed as a gentler retinoid delivery form). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned/available.

What is the Margin of Safety for Retinyl Dimethylglycylprolinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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