Regulatory Status
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Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
High concern: Hydroxyanthraquinone with positive Ames test signals in some studies; EMA flagged hydroxyanthracene derivatives for genotoxicity; potential phototoxicity; must be used at very low concentrations with full safety substantiation; monitor EU regulatory developments as anthraquinones are under increasing scrutiny
Frequently Asked Questions
Is Rhein safe in cosmetics?
High concern: Hydroxyanthraquinone with positive Ames test signals in some studies; EMA flagged hydroxyanthracene derivatives for genotoxicity; potential phototoxicity; must be used at very low concentrations with full safety substantiation; monitor EU regulatory developments as anthraquinones are under increasing scrutiny The EU classifies Rhein as "permitted". Safety rating: MODERATE.
Is Rhein allowed in the EU?
Rhein EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Rhein do in cosmetics?
Rhein functions as: Skin Conditioning (anthraquinone compound found in rhubarb, cascara, senna). It is classified as a cosmetic ingredient in our database. CAS number: 478-43-3.
What is the Margin of Safety for Rhein?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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