CAS Number
63231-63-0
Function
Skin Conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted for cosmetic use; no specific restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Source verification critical: yeast-derived RNA is standard and well-tolerated; novel siRNA actives claiming gene-level activity are a distinct regulatory category and may face claim substantiation scrutiny. Ensure supplier COA specifies biological source and microbial limits

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Concern Level: Low

Frequently Asked Questions

Is RNA safe in cosmetics?

Source verification critical: yeast-derived RNA is standard and well-tolerated; novel siRNA actives claiming gene-level activity are a distinct regulatory category and may face claim substantiation scrutiny. Ensure supplier COA specifies biological source and microbial limits The EU classifies RNA as "permitted". Safety rating: GOOD.

Is RNA allowed in the EU?

RNA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does RNA do in cosmetics?

RNA functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 63231-63-0.

What is the Margin of Safety for RNA?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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